NETWORK-BASED CLUSTERING UNVEILS INTERCONNECTED LANDSCAPES OF GENOMIC AND CLINICAL FEATURES ACROSS MYELOID MALIGNANCIES

Network-based clustering unveils interconnected landscapes of genomic and clinical features across myeloid malignancies

Abstract Myeloid malignancies exhibit considerable heterogeneity with overlapping clinical and genetic features among subtypes.We present a data-driven approach that integrates mutational features and clinical covariates at diagnosis within networks of their probabilistic relationships, enabling the discovery of patient subgroups.A key strength is

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Synthesis and Solution Region Optimization Method of a Straight-line Mechanism with Instant Center at Infinity

A set of mechanism synthesis universal model is presented in this study.Given the expected straight-line and a fixed pivot, this model can solve the synthesis problem of the straight-line guide mechanism when the instant CLIPS center tends to infinity in the coupler plane.In addition, mechanism synthesis formulas are derived and an example of mecha

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The Collagen-Based Medical Device MD-Tissue Acts as a Mechanical Scaffold Influencing Morpho-Functional Properties of Cultured Human Tenocytes

Mechanotransduction is the ability of cells to translate mechanical stimuli into biochemical signals that can ultimately influence gene expression, cell morphology and cell fate.Tenocytes are responsible for tendon mechanical adaptation converting mechanical stimuli imposed during mechanical loading, thus affecting extracellular matrix homeostasis.

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